EMPATHY MEDIATES THE RELATIONSHIP BETWEEN MOTIVATIONS AFTER TRANSGRESSION AND FORGIVENESS


Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers

Abstract Killer meiotic drivers (KMDs) skew allele transmission in their favor by killing meiotic progeny not inheriting the driver allele.Despite their widespread presence in eukaryotes, the molecular mechanisms behind their selfish behavior are poorly Computer Cable understood.In several fission yeast species, single-gene KMDs belonging to the wt

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Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progressionResearch in context

Background: Triple-negative breast cancer (TNBC) remains difficult to be targeted.SET and cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting inhibitors of protein phosphatase 2A (PP2A) and frequently overexpressed in cancers, whereas reactivating PP2A activity has been postulated as an anti-cancer strategy.Here

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